Drug Information

Drug General Information
Drug ID
D08IFL
Former ID
DAP000815
Drug Name
Meclofenamic acid
Synonyms
Arquel; Meclofenamate; Meclomen; Acide meclofenamique; Acido meclofenamico; Acidum meclofenamicum; Meclophenamic acid; CL 583; INF 4668; Acide meclofenamique [INN-French]; Acido meclofenamico [INN-Spanish]; Acidum meclofenamicum [INN-Latin]; INF-4668; Meclomen (free acid); Meclofenamic acid (USAN/INN); Meclofenamic acid [USAN:INN:BAN]; N-(2,6-Dichloro-3-methylphenyl)anthranilic acid; N-(2,6-Dichloro-m-tolyl)anthranilic acid; N-(3-Methyl-2,6-dichlorophenyl)anthranilic acid; 2-((2,6-Dichloro-3-methylphenyl)amino)benzoic acid; 2-(2,6-Dichloro-3-methylphenyl)aminobenzoic acid; 2-(2,6-dichloro-3-methylanilino)benzoic acid; 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid
Drug Type
Small molecular drug
Indication Joint and muscular pain; Ankylosing spondylitis [ICD9: 719.4, 729.1, 338, 780, 720; ICD10:M25.5, M79.1, G89, R52, M08.1, M45] Approved [536575], [542233], [551871]
Therapeutic Class
Analgesics
Structure
Download
2D MOL

3D MOL
Formula
C14H11Cl2NO2
InChI
InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)
InChIKey
SBDNJUWAMKYJOX-UHFFFAOYSA-N
CAS Number
CAS 644-62-2
PubChem Compound ID
4037
PubChem Substance ID
9328, 400193, 840128, 7457972, 7849400, 7979877, 8152527, 11335679, 11360918, 11363787, 11366349, 11368911, 11371551, 11373614, 11377073, 11461890, 11466234, 11467354, 11484706, 11485848, 11488861, 11490302, 11491853, 11494707, 14800267, 24424562, 29223148, 46507887, 47365144, 47440206, 47588953, 47662236, 47959696, 48110417, 48110418, 48334447, 49846785, 49870448, 50103859, 50264248, 53788368, 57322106, 85173910, 85788470, 85789196, 103173431, 103828114, 104305246, 117467594, 118313497
SuperDrug ATC ID
M01AG04; M02AA18
SuperDrug CAS ID
cas=000644622
Target and Pathway
Target(s) Cyclooxygenase Target Info Inhibitor [537872], [537903]
References
Ref 536575Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.
Ref 542233(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7219).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537872Interactions of PGH synthase isozymes-1 and -2 with NSAIDs. Ann N Y Acad Sci. 1994 Nov 15;744:50-7.
Ref 537903Pharmacology of prostaglandin endoperoxide synthase isozymes-1 and -2. Ann N Y Acad Sci. 1994 Apr 18;714:136-42.

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