Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08KDP
|
||||
| Former ID |
DNC000257
|
||||
| Drug Name |
AS-8112
|
||||
| Indication | Emesis [ICD9: 787; ICD10:R11] | Terminated | [1] | ||
| Company |
Dainippon
|
||||
| CAS Number |
CAS 13074-00-5
|
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine receptor 3A | Target Info | Antagonist | [2] | |
| D(3) dopamine receptor | Target Info | Antagonist | [2] | ||
| KEGG Pathway | Serotonergic synapsehsa04080:Neuroactive ligand-receptor interaction | ||||
| Dopaminergic synapse | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | 5HT3 type receptor mediated signaling pathway | ||||
| Reactome | Ligand-gated ion channel transportR-HSA-390651:Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Iron uptake and transportWP58:Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009088) | ||||
| REF 2 | Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. | ||||
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