Drug General Information
Drug ID	D08LVF
Former ID	DIB004715
Drug Name	Nitecapone
Synonyms	OR-462
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Discontinued in Phase 2	[544833]
Company	Orion Corp
Structure		Download 2D MOL 3D MOL
Formula	C12H11NO6
Canonical SMILES	c1([N+](=O)[O-])c(c(cc(C=C(C(=O)C)C(=O)C)c1)O)O
CAS Number	CAS 116313-94-1
PubChem Compound ID	5464105
Target and Pathway
Target(s)	Catechol-O-methyl-transferase	Target Info	Modulator	[531946]
BioCyc Pathway	L-dopa degradation
	Dopamine degradation
	Noradrenaline and adrenaline degradation
KEGG Pathway	Steroid hormone biosynthesis
	Tyrosine metabolism
	Metabolic pathways
	Dopaminergic synapse
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
	Dopamine receptor mediated signaling pathway
PathWhiz Pathway	Tyrosine Metabolism
WikiPathways	Methylation Pathways
	Metapathway biotransformation
	Estrogen metabolism
	Biogenic Amine Synthesis
	Dopamine metabolism
	Phase II conjugation
	Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 544833	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001267)
Ref 531946	Effect of a novel catechol-O-methyltransferase inhibitor, nitecapone, on the metabolism of L-dopa in healthy volunteers. Clin Neuropharmacol. 1990 Oct;13(5):436-47.

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