Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08LZI
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| Former ID |
DIB006663
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| Drug Name |
NS-220
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| Synonyms |
R-1593; Cis-2-Methyl-5-[4-[5-methyl-2-(4-methylphenyl)oxazol-4-yl]butyl]-1,3-dioxane-2-carboxylic acid
|
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| Drug Type |
Small molecular drug
|
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| Structure |
|
Download2D MOL |
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| Formula |
C21H27NO5
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| InChI |
InChI=1S/C21H27NO5/c1-14-8-10-17(11-9-14)19-22-18(15(2)27-19)7-5-4-6-16-12-25-21(3,20(23)24)26-13-16/h8-11,16H,4-7,12-13H2,1-3H3,(H,23,24)/t16-,21+
|
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| InChIKey |
IMYPSTHZBIWMNA-NBEIKUQISA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Peroxisome proliferator activated receptor alpha | Target Info | Agonist | [529786], [551871] | |
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | ||||
| Reactome | RORA activates gene expression | ||||
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | |||||
| PPARA activates gene expression | |||||
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | |||||
| Transcriptional activation of mitochondrial biogenesis | |||||
| Activation of gene expression by SREBF (SREBP) | |||||
| Transcriptional regulation of white adipocyte differentiation | |||||
| Nuclear Receptor transcription pathway | |||||
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
| Circadian Clock | |||||
| WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Estrogen Receptor Pathway | |||||
| PPAR Alpha Pathway | |||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
| Transcriptional Regulation of White Adipocyte Differentiation | |||||
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | |||||
| Activation of Gene Expression by SREBP (SREBF) | |||||
| Adipogenesis | |||||
| SREBF and miR33 in cholesterol and lipid homeostasis | |||||
| Circadian Clock | |||||
| Nuclear Receptors | |||||
| References | |||||
| Ref 539744 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2678). | ||||
| Ref 547609 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017798) | ||||
| Ref 529786 | Modulation of PPAR receptor subtype selectivity of the ligands: aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6471-5. | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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