TTD | Drug: D08MLH

Drug General Information
Drug ID	D08MLH
Former ID	DIB009237
Drug Name	TUG-469
Synonyms	Free fatty acid receptor 1 agonist (type 2 diabetes), University of Souther Denmark
Indication	Non-insulin dependent diabetes [ICD10:E11.9]		Investigative	[543582]
Company	University of Southern Denmark
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1ccc(c(c1)C)c1cccc(c1)CNc1ccc(cc1)CCC(=O)O
Target and Pathway
Target(s)	GPR40	Target Info	Agonist	[543582]
KEGG Pathway	Insulin secretion
Reactome	G alpha (q) signalling events
Reactome	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
WikiPathways	GPCRs, Class A Rhodopsin-like
	Incretin Synthesis, Secretion, and Inactivation
	Gastrin-CREB signalling pathway via PKC and MAPK
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543582	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 225).
Ref 543582	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 225).

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Drug Information