Drug Information

Drug General Information
Drug ID
D08PAC
Former ID
DNC004053
Drug Name
L-371257
Drug Type
Small molecular drug
Indication Discovery agent Terminated [539425], [546463]
Structure
Download
2D MOL

3D MOL
Formula
C28H33N3O6
InChI
InChI=1S/C28H33N3O6/c1-19(32)29-15-11-22(12-16-29)37-23-7-8-24(26(17-23)35-2)27(33)30-13-9-21(10-14-30)31-25-6-4-3-5-20(25)18-36-28(31)34/h3-8,17,21-22H,9-16,18H2,1-2H3
InChIKey
WDERJSQJYIJOPD-UHFFFAOYSA-N
PubChem Compound ID
6918320
PubChem Substance ID
12015018, 14786780, 17194813, 29215539, 43529700, 57371881, 78674837, 85220895, 103194475, 103938699, 114787780, 134341258, 135650475, 135698230, 137142842, 152344395, 162222306, 163123659, 204370394, 230833024, 241375914, 249617559, 251963118, 252156489
Target and Pathway
Target(s) Vasopressin V1a receptor Target Info Inhibitor [530975]
Oxytocin receptor Target Info Inhibitor [530975]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contractionhsa04020:Calcium signaling pathway
cAMP signaling pathway
Oxytocin signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Oxytocin receptor mediated signaling pathway
Reactome Vasopressin-like receptors
G alpha (q) signalling eventsR-HSA-388479:Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Myometrial Relaxation and Contraction Pathways
Oxytocin signaling
GPCR downstream signaling
References
Ref 539425(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2252).
Ref 546463Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008273)
Ref 530975J Med Chem. 2010 Sep 23;53(18):6525-38.Oral oxytocin antagonists.

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