Drug Information

Drug General Information
Drug ID
D08PBE
Former ID
DIB018240
Drug Name
[3H]AP4
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538889]
Structure
Download
2D MOL
Formula
C4H10NO5P
InChI
InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
InChIKey
DDOQBQRIEWHWBT-VKHMYHEASA-N
PubChem Compound ID
179394
PubChem Substance ID
3153190, 4252812, 7978716, 10259084, 11113375, 11457587, 11459535, 14818549, 24891296, 26651777, 26758214, 33502534, 49896033, 50104307, 57395670, 78666740, 81093357, 90458771, 103205265, 103920819, 104429542, 117682323, 124635408, 124877291, 124877292, 127719431, 132522189, 134345882, 135158089, 135650507, 135651136, 140341569, 162093643, 163688614, 228129920, 241181546
Target and Pathway
Target(s) Metabotropic glutamate receptor 4 Target Info Agonist [525456]
Metabotropic glutamate receptor 8 Target Info Agonist [525476]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transductionhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signaling
GPCRs, Other
References
Ref 538889(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1412).
Ref 525456Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13.
Ref 525476Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res. 1999 Apr 20;67(2):201-10.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.