Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08PJK
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| Former ID |
DIB018221
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| Drug Name |
[3H]5-CT
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| Synonyms |
tritiated 5-carbamidotryptamine; [3H]5-carboxamidotryptamine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [525563] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C11H13N3O
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| InChI |
InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)/i3T2,4T2
|
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| InChIKey |
WKZLNEWVIAGNAW-DOMYTETQSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 7 receptor | Target Info | Agonist | [525765] | |
| 5-hydroxytryptamine 6 receptor | Target Info | Agonist | [543365] | ||
| 5-ht5b receptor | Target Info | Agonist | [534827] | ||
| 5-hydroxytryptamine 5A receptor | Target Info | Agonist | [526046] | ||
| 5-hydroxytryptamine 1D receptor | Target Info | Agonist | [525563] | ||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathway | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP734:Serotonin Receptor 4/6/7 and NR3C Signaling | |||||
| GPCR downstream signalingWP58:Monoamine GPCRs | |||||
| GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway | |||||
| References | |||||
| Ref 525563 | Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed. FEBS Lett. 1999 Jul 30;456(1):63-7. | ||||
| Ref 525765 | [(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors. Br J Pharmacol. 2000 May;130(2):409-17. | ||||
| Ref 526046 | Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution. Eur J Pharmacol. 2001 Apr 27;418(3):157-67. | ||||
| Ref 534827 | Putative 5-ht5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation. Ann N Y Acad Sci. 1998 Dec 15;861:85-90. | ||||
| Ref 543365 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11). | ||||
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