Drug General Information
Drug ID	D08PMW
Former ID	DIB009901
Drug Name	BMS-223131
Synonyms	4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)quinolin-2(1H)-one
Indication	Erectile dysfunction [ICD9: 302.72, 607.84; ICD10:F52.2, N48.4]		Phase 2	[527426]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Maxi K potassium channel	Target Info	Modulator	[527426]
KEGG Pathway	cGMP-PKG signaling pathway
	Vascular smooth muscle contraction
	Insulin secretion
	Salivary secretion
	Pancreatic secretion
Reactome	cGMP effects
WikiPathways	Potassium Channels
	Platelet homeostasis
References
Ref 527426	Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception. J Pharmacol Exp Ther. 2005 May;313(2):840-7. Epub 2005 Feb 8.
Ref 527426	Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception. J Pharmacol Exp Ther. 2005 May;313(2):840-7. Epub 2005 Feb 8.

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