Drug Information

Drug General Information
Drug ID
D08PYJ
Former ID
DNC007403
Drug Name
MAGGIEMYCIN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528798]
Structure
Download
2D MOL

3D MOL
Formula
C22H18O9
Canonical SMILES
CCC1(CC(=O)C2=C(C3=C(C(=C2C1C(=O)OC)O)C(=O)C4=C(C3=O)C(<br />=CC=C4)O)O)O
InChI
1S/C22H18O9/c1-3-22(30)7-10(24)12-13(16(22)21(29)31-2)20(28)14-15(19(12)27)18(26)11-8(17(14)25)5-4-6-9(11)23/h4-6,16,23,27-28,30H,3,7H2,1-2H3
InChIKey
FCUPTGDGQULLKX-UHFFFAOYSA-N
PubChem Compound ID
133657
Target and Pathway
Target(s) Integrin alpha-2 Target Info Inhibitor [528798]
KEGG Pathway Phagosome
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Platelet activation
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Pathways in cancer
Proteoglycans in cancer
Small cell lung cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Integrin signalling pathway
Pathway Interaction Database Beta1 integrin cell surface interactions
Integrin family cell surface interactions
Arf6 trafficking events
CXCR4-mediated signaling events
Plexin-D1 Signaling
Syndecan-2-mediated signaling events
VEGFR3 signaling in lymphatic endothelium
Reactome Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
CHL1 interactions
Platelet Adhesion to exposed collagen
WikiPathways TGF beta Signaling Pathway
Focal Adhesion
Human Complement System
Extracellular matrix organization
Interleukin-11 Signaling Pathway
Arrhythmogenic Right Ventricular Cardiomyopathy
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
Platelet Adhesion to exposed collagen
Integrin-mediated Cell Adhesion
L1CAM interactions
Integrin cell surface interactions
References
Ref 528798J Med Chem. 2007 May 31;50(11):2742-6. Epub 2007 Apr 21.Small molecule designed to target metal binding site in the alpha2I domain inhibits integrin function.
Ref 528798J Med Chem. 2007 May 31;50(11):2742-6. Epub 2007 Apr 21.Small molecule designed to target metal binding site in the alpha2I domain inhibits integrin function.

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