Drug Information

Drug General Information
Drug ID
D08RQW
Former ID
DIB020359
Drug Name
MK-5046
Synonyms
MK 5046; MK5046
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541356]
Structure
Download
2D MOL
Formula
C20H18F6N4O
InChI
InChI=1S/C20H18F6N4O/c21-19(22,23)17(6-7-17)10-14-12-27-16(29-14)11-18(31,20(24,25)26)13-2-4-15(5-3-13)30-9-1-8-28-30/h1-5,8-9,12,31H,6-7,10-11H2,(H,27,29)/t18-/m0/s1
InChIKey
UJINBEQCDMOAHM-SFHVURJKSA-N
PubChem Compound ID
49871766
PubChem Substance ID
104546702, 124973485, 125086991, 178102791, 229510294, 244897299, 252813931
Target and Pathway
Target(s) Bombesin receptor Target Info Agonist [531243]
Gastrin-releasing peptide receptor Target Info Agonist [532441]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRsWP455:GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCRs, Other
References
Ref 541356(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6170).
Ref 531243Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist. J Pharmacol Exp Ther. 2011 Feb;336(2):356-64.
Ref 532441Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptors. J Pharmacol Exp Ther. 2013 Oct;347(1):100-16.

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