Drug Information

Drug General Information
Drug ID
D08RUX
Former ID
DIB000506
Drug Name
Z-321
Synonyms
1-[3-(2-Indanylacetyl)thiazolidin-4(R)-ylcarbonyl]pyrrolidine; 1-[N-(2-Indanylacetyl)-4-thia-L-prolyl]pyrrolidine
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Discontinued in Phase 1 [545389]
Structure
Download
2D MOL

3D MOL
Formula
C17H28O3
Canonical SMILES
CCC1(C(O1)CCC(=CCCC(=CC(=O)OC)C)C)C
InChI
1S/C17H28O3/c1-6-17(4)15(20-17)11-10-13(2)8-7-9-14(3)12-16(18)19-5/h8,12,15H,6-7,9-11H2,1-5H3/b13-8+,14-12+/t15-,17+/m1/s1
InChIKey
CPVQJXZBSGXTGJ-TZDLBHCHSA-N
CAS Number
CAS 130849-58-0
PubChem Compound ID
5459796
PubChem Substance ID
7422, 8143324, 11688149, 16146269, 39442699, 57395125, 80945143, 85291364, 113998849, 125310793, 135213832, 180112144, 226491026, 241180575
Target and Pathway
Target(s) Prolyl endopeptidase Target Info Modulator [534340]
KEGG Pathway Renin-angiotensin system
PANTHER Pathway Vasopressin synthesis
References
Ref 545389Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003089)
Ref 534340Z-321, a prolyl endopeptidase inhibitor, augments the potentiation of synaptic transmission in rat hippocampal slices. Behav Brain Res. 1997 Feb;83(1-2):213-6.

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