Drug Information

Drug General Information
Drug ID
D08TBU
Former ID
DNC010157
Drug Name
Diphenyl(piperidin-4-yl)methanol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530299]
Structure
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2D MOL

3D MOL
Formula
C18H21NO
Canonical SMILES
C1CNCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)O
InChI
1S/C18H21NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17,19-20H,11-14H2
InChIKey
ZMISODWVFHHWNR-UHFFFAOYSA-N
PubChem Compound ID
15723
Target and Pathway
Target(s) Histamine H1 receptor Target Info Inhibitor [530299]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530299Bioorg Med Chem Lett. 2009 Sep 1;19(17):5043-7. Epub 2009 Aug 5.Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.
Ref 530299Bioorg Med Chem Lett. 2009 Sep 1;19(17):5043-7. Epub 2009 Aug 5.Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.

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