Drug General Information
Drug ID	D08TKV
Former ID	DIB009216
Drug Name	SKF-97426
Synonyms	SKF-97426A
Indication	Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78]		Discontinued in Phase 2	[545280]
Company	SmithKline Beecham plc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(C(=C)C)OCCOC(=O)C(=C)C.C(=O)(C(=C)C)OCCCCCCCCCCC[<br />N+](C)(C)C.[Cl-]
CAS Number	CAS 152060-21-4
Target and Pathway
Target(s)	Bile acid receptor	Target Info	Modulator	[533930]
KEGG Pathway	Bile secretion
Pathway Interaction Database	RXR and RAR heterodimerization with other nuclear receptor
Reactome	Recycling of bile acids and salts
	PPARA activates gene expression
	Endogenous sterols
WikiPathways	Nuclear Receptors in Lipid Metabolism and Toxicity
	Nuclear Receptors Meta-Pathway
	Farnesoid X Receptor Pathway
	Drug Induction of Bile Acid Pathway
References
Ref 545280	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002680)
Ref 533930	SK&amp;F 97426-A a more potent bile acid sequestrant and hypocholesterolaemic agent than cholestyramine in the hamster. Atherosclerosis. 1993 Jun;101(1):51-60.

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