Drug General Information
Drug ID	D08TLI
Former ID	DIB016191
Drug Name	E-4716
Synonyms	Mapinastine
Indication	Respiratory disease [ICD10:J00-J99]		Phase 2	[527345]
Company	Laboratorios Dr Esteve SA
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(nc2c(n1CCOCC)cccc2)CN1CCN(CC1)CCCCn1nccc1.C(=O)(/C=C<br />\C(=O)O)O.C(=O)(/C=C\C(=O)O)O
CAS Number	CAS 179188-69-3
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Modulator	[527345]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 527345	Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children. Br J Clin Pharmacol. 2005 Jan;59(1):43-53.
Ref 527345	Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children. Br J Clin Pharmacol. 2005 Jan;59(1):43-53.

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