TTD | Drug: D08TWT

Drug General Information
Drug ID	D08TWT
Former ID	DIB018780
Drug Name	AGN192093
Synonyms	AGN-192093; AGN 192093
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540335]
Structure		Download 2D MOL
Formula	C21H34O5
InChI	InChI=1S/C21H34O5/c1-2-3-7-10-16(23)12-13-18-17(11-8-5-4-6-9-14-22)19-15-20(18)26-21(24)25-19/h5,8,12-13,16-20,22-23H,2-4,6-7,9-11,14-15H2,1H3/b8-5-,13-12+/t16-,17+,18+,19-,20-/m0/s1
InChIKey	PTIUXNGGNGQHQK-KTEVXADTSA-N
PubChem Compound ID	11968293
PubChem Substance ID	36465084, 57377798, 79305712, 178100404
Target and Pathway
Target(s)	Thromboxane A2 receptor	Target Info	Agonist	[534256]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Platelet activation
Reactome	Prostanoid ligand receptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
	Thromboxane signalling through TP receptor
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540335	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3387).
Ref 534256	Evidence for human thromboxane receptor heterogeneity using a novel series of 9,11-cyclic carbonate derivatives of prostaglandin F2 alpha. Br J Pharmacol. 1996 Mar;117(6):1171-80.

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Drug Information