Drug Information

Drug General Information
Drug ID
D08VGT
Former ID
DIB000950
Drug Name
BMY-30129
Synonyms
BMS-181162; 4-(3-Carboxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2(Z),4(E),6(E),8(E)-nonatetraenoicacid
Indication Pruritus [ICD9: 698; ICD10:L29] Discontinued in Phase 2 [545846]
Structure
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2D MOL

3D MOL
Canonical SMILES
C\\C(=C/C=C(/C(=C/C(=O)O)/C)\\c1cccc(c1)C(=O)O)\\C=C\\C<br />2=C(C)CCCC2(C)C
InChI
1S/C27H32O4/c1-18(12-14-24-19(2)8-7-15-27(24,4)5)11-13-23(20(3)16-25(28)29)21-9-6-10-22(17-21)26(30)31/h6,9-14,16-17H,7-8,15H2,1-5H3,(H,28,29)(H,30,31)/b14-12+,18-11+,20-16+,23-13-
InChIKey
XKKDQOHDTASHCE-KZEPKJRYSA-N
Target and Pathway
Target(s) Phospholipase A2 Target Info Inhibitor [533821], [551871]
BioCyc Pathway Phospholipases
KEGG Pathway Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorption
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
Reactome Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
WikiPathways Glycerophospholipid biosynthesis
References
Ref 545846Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005019)
Ref 533821Inhibitor of phospholipase A2 blocks eicosanoid and platelet activating factor biosynthesis and has topical anti-inflammatory activity. J Pharmacol Exp Ther. 1994 Nov;271(2):852-9.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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