Drug General Information
Drug ID	D08VMW
Former ID	DIB015816
Drug Name	MP-529
Synonyms	SGI-1097; SGI-1215; SGI-498; SGI-503; Oral aurora kinase inhibitor (cancer), Montigen
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Investigative	[543524]
Company	Montigen Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	O=S(=O)(c1ccc(NC(=S)N2CCN(c3ncnc4c3c3c(cc(c(c3)OC)OC)[n<br />H]4)CC2)cc1)Nc1ccc(cc1)F
Target and Pathway
Target(s)	Aurora protein kinase	Target Info	Inhibitor	[543524]
KEGG Pathway	Oocyte meiosis
Reactome	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
	Separation of Sister Chromatids
	Resolution of Sister Chromatid Cohesion
	RHO GTPases Activate Formins
WikiPathways	EGF/EGFR Signaling Pathway
	JAK/STAT
	Gastric Cancer Network 1
	Integrated Breast Cancer Pathway
	APC/C-mediated degradation of cell cycle proteins
References
Ref 543524	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936).
Ref 543524	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.