Drug General Information
Drug ID	D08WVA
Former ID	DIB011657
Drug Name	UK-224671
Synonyms	UK-369202; UK-416960
Drug Type	Small molecular drug
Indication	Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32]		Discontinued in Phase 1	[546880]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Formula	C24H35Cl2N5O3S
Canonical SMILES	S(=O)(=O)(N1CCN(C2CN(C2)CC[C@]2(CN(C(=O)CC2)CC2CC2)c2cc<br />(c(cc2)Cl)Cl)CC1)C
CAS Number	CAS 178309-91-6
PubChem Compound ID	9915372
Target and Pathway
Target(s)	NK-2 receptor	Target Info	Antagonist	[525841]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546880	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010850)
Ref 525841	Pharmacokinetics and metabolism of a sulphamide NK2 antagonist in rat, dog and human. Xenobiotica. 2000 Jun;30(6):627-42.

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