Drug Information

Drug General Information
Drug ID
D08YQT
Former ID
DNC000189
Drug Name
AM251
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540277]
Structure
Download
2D MOL

3D MOL
Formula
C22H21Cl2IN4O
InChI
InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
InChIKey
BUZAJRPLUGXRAB-UHFFFAOYSA-N
CAS Number
CAS 183232-66-8
PubChem Compound ID
2125
PubChem Substance ID
7427143, 8151442, 11113928, 11120000, 11120488, 11120976, 11121590, 11122070, 11147083, 11362659, 11365221, 11367783, 11370589, 11370590, 11373384, 11375945, 14886159, 24891069, 26719791, 26752081, 26752082, 29221304, 46386990, 47959459, 48334204, 49681171, 49681811, 49689351, 50068054, 50104735, 53790533, 56311975, 57321157, 79751999, 85209665, 85788727, 91746244, 92308639, 92309941, 99300855, 99302373, 103100713, 103209134, 104046577, 104299676, 113635230, 117540808, 124659102, 125334727, 127571931
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Antagonist [535887]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540277(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3317).
Ref 535887Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception. J Pharmacol Exp Ther. 2004 Apr;309(1):56-63. Epub 2004 Jan 12.

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