Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08ZCL
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| Former ID |
DNC000871
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| Drug Name |
Leu-enkephalin
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
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Download2D MOL |
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| Formula |
C28H37N5O7
|
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| InChI |
InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)
|
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| InChIKey |
URLZCHNOLZSCCA-UHFFFAOYSA-N
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| CAS Number |
CAS 380843-75-4
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| PubChem Compound ID | |||||
| PubChem Substance ID |
463335, 6899007, 8149844, 8152458, 11336185, 11361424, 11364323, 11366885, 11369447, 11372501, 11374455, 11377609, 11462396, 11484929, 11488993, 11491336, 11492862, 11495243, 26681013, 29223017, 47662380, 47662381, 47736579, 48185073, 49997088, 50123045, 57309626, 57322044, 79293996, 85085815, 85209574, 99302098, 103177895, 103852107, 104304853, 117367196, 124638086, 125701316, 125821620, 126686033, 129410134, 135003516, 135651802, 137067622, 140543347, 162092134, 163144251, 177748293, 179038761, 184532295
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| ChEBI ID |
ChEBI:39112
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| Target and Pathway | |||||
| Target(s) | Delta-type opioid receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| Sphingolipid signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Enkephalin release | |||||
| Opioid proenkephalin pathway | |||||
| Opioid proopiomelanocortin pathway | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1613). | ||||
| REF 2 | Inverse agonist action of Leu-enkephalin at delta(2)-opioid receptors mediates spinal antianalgesia. J Pharmacol Exp Ther. 2001 May;297(2):582-9. | ||||
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