Drug General Information
Drug ID	D08ZZX
Former ID	DNC012769
Drug Name	4-(3-Methoxy-phenyl)-isoxazolidine-3,5-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533567]
Structure		Download 2D MOL 3D MOL
Formula	C10H9NO4
Canonical SMILES	COC1=CC=CC(=C1)C2C(=O)NOC2=O
InChI	1S/C10H9NO4/c1-14-7-4-2-3-6(5-7)8-9(12)11-15-10(8)13/h2-5,8H,1H3,(H,11,12)
InChIKey	GTLJNZXLCZDZRN-UHFFFAOYSA-N
PubChem Compound ID	12762411
Target and Pathway
Target(s)	Aldose reductase	Target Info	Inhibitor	[533567]
BioCyc Pathway	Methylglyoxal degradation III
	Acetone degradation I (to methylglyoxal)
KEGG Pathway	Pentose and glucuronate interconversions
	Fructose and mannose metabolism
	Galactose metabolism
	Glycerolipid metabolism
	Metabolic pathways
NetPath Pathway	IL1 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Fructose and Mannose Degradation
	Pyruvate Metabolism
	Pterine Biosynthesis
	Glycerolipid Metabolism
	Galactose Metabolism
WikiPathways	Metapathway biotransformation
	Polyol Pathway
	Metabolism of steroid hormones and vitamin D
References
Ref 533567	J Med Chem. 1982 Jun;25(6):745-7.Isoxazolidine-3,5-diones as lens aldose reductase inhibitors.
Ref 533567	J Med Chem. 1982 Jun;25(6):745-7.Isoxazolidine-3,5-diones as lens aldose reductase inhibitors.

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