Drug General Information
Drug ID	D09ADT
Former ID	DNC000130
Drug Name	ABT-418
Drug Type	Small molecular drug
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Discontinued in Phase 2	[545652]
Structure		Download 2D MOL 3D MOL
Formula	C9H14N2O
Canonical SMILES	CC1=NOC(=C1)C2CCCN2C
InChI	1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m0/s1
InChIKey	ILLGYRJAYAAAEW-QMMMGPOBSA-N
CAS Number	CAS 147402-53-7
PubChem Compound ID	119380
PubChem Substance ID	7978627, 10238470, 15147104, 15147105, 29217480, 29300274, 50064460, 57339467, 75476358, 90341586, 103169373, 103943417, 104408194, 128184977, 132556065, 134222090, 134339649, 135075158, 137132961, 142603802, 162219930, 224987522, 226553057, 251962931
Target and Pathway
Target(s)	Neuronal acetylcholine receptor protein, alpha-4 chain	Target Info	Agonist	[537889]
	Nicotinic acetylcholine receptor	Target Info	Agonist	[534879]
	Neuronal acetylcholine receptor protein, beta-2 chain	Target Info	Agonist	[535007], [537889]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Nicotine addiction
PANTHER Pathway	Nicotinic acetylcholine receptor signaling pathway
	Nicotine pharmacodynamics pathwayP00044:Nicotinic acetylcholine receptor signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Highly sodium permeable acetylcholine nicotinic receptors
	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
	Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors
	Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Nicotine Activity on Dopaminergic NeuronsWP706:SIDS Susceptibility Pathways
	Nicotine Activity on Dopaminergic Neurons
References
Ref 545652	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004036)
Ref 534879	Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats. Psychopharmacology (Berl). 1999 May;144(2):175-82.
Ref 535007	Nicotine, brain nicotinic receptors, and neuropsychiatric disorders. Arch Med Res. 2000 Mar-Apr;31(2):131-44.
Ref 537889	(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization. J Pharmacol Exp Ther. 1994 Jul;270(1):319-28.

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