Drug General Information
Drug ID	D09AFJ
Former ID	DIB016340
Drug Name	SR-121787
Synonyms	SR-121566; SR-121566a
Drug Type	Small molecular drug
Indication	Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Discontinued in Phase 2	[546615]
Company	Sanofi-Synthelabo
Structure		Download 2D MOL 3D MOL
Formula	C27H37N5O6S
Canonical SMILES	c1(nc(cs1)c1ccc(/C(=N/C(=O)OCC)/N)cc1)N(CCC(=O)OCC)C1CC<br />N(CC(=O)OCC)CC1
PubChem Compound ID	44343896
Target and Pathway
Target(s)	Glycoprotein IIb/IIIa receptor	Target Info	Modulator
Reactome	Platelet degranulation
	Elastic fibre formation
	PECAM1 interactions
	Molecules associated with elastic fibres
	Integrin cell surface interactions
	Syndecan interactions
	ECM proteoglycans
	Integrin alphaIIb beta3 signaling
	GRB2:SOS provides linkage to MAPK signaling for Integrins
	p130Cas linkage to MAPK signaling for integrins
	VEGFA-VEGFR2 Pathway
	MAP2K and MAPK activation
WikiPathways	Focal Adhesion
	Hematopoietic Stem Cell Differentiation
	Human Complement System
	Extracellular matrix organization
	Arrhythmogenic Right Ventricular Cardiomyopathy
	Integrin-mediated Cell Adhesion
	L1CAM interactions
	Integrin cell surface interactions
	Integrin alphaIIb beta3 signaling
References
Ref 546615	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009197)

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