Drug General Information
Drug ID
D09AID
Former ID
DIB019384
Drug Name
compound 25b
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531897]
Structure
Download
2D MOL
Formula
C28H35ClN6O3
InChI
InChI=1S/C28H35ClN6O3/c1-37-25-20-8-7-19(35-10-12-38-13-11-35)6-4-16(20)5-9-22(25)32-28-31-15-21(29)27(34-28)33-24-18-3-2-17(14-18)23(24)26(30)36/h2-3,5,9,15,17-19,23-24H,4,6-8,10-14H2,1H3,(H2,30,36)(H2,31,32,33,34)/t17-,18+,19+,23+,24-/m1/s1
InChIKey
LAJAFFLJAJMYLK-CVOKMOJFSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) FES proto-oncogene, tyrosine kinase Target Info Inhibitor [531897]
ribosomal protein S6 kinase, 90kDa, polypeptide 6 Target Info Inhibitor [531897]
ribosomal protein S6 kinase, 90kDa, polypeptide 2 Target Info Inhibitor [531897]
Serine/threonine-protein kinase Chk2 Target Info Inhibitor [531897]
NUAK family, SNF1-like kinase, 1 Target Info Inhibitor [531897]
ribosomal protein S6 kinase, 90kDa, polypeptide 3 Target Info Inhibitor [531897]
fer (fps/fes related) tyrosine kinase Target Info Inhibitor [531897]
ALK tyrosine kinase receptor Target Info Inhibitor [531897]
KEGG Pathway Cell cycle
p53 signaling pathway
HTLV-I infectionhsa05223:Non-small cell lung cancer
Pathway Interaction Database ATM pathway
FOXM1 transcription factor network
p53 pathway
PLK3 signaling events
Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
WikiPathways DNA Damage Response
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell Cycle
miRNA Regulation of DNA Damage ResponseWP2848:Differentiation Pathway
References
Ref 531897Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem. 2012 May 24;55(10):4580-93.
Ref 531897Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem. 2012 May 24;55(10):4580-93.

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