Drug General Information
Drug ID	D09AYK
Former ID	DNC012999
Drug Name	3-ethoxycarbonyl-4-quinolone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528134]
Structure		Download 2D MOL 3D MOL
Formula	C12H11NO3
Canonical SMILES	CCOC(=O)C1=CNC2=CC=CC=C2C1=O
InChI	1S/C12H11NO3/c1-2-16-12(15)9-7-13-10-6-4-3-5-8(10)11(9)14/h3-7H,2H2,1H3,(H,13,14)
InChIKey	YBEOYBKKSWUSBR-UHFFFAOYSA-N
PubChem Compound ID	220876
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[528134]
	Gamma-aminobutyric acid receptor subunit beta-2	Target Info	Inhibitor	[528134]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[528134]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[528134]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Serotonergic synapse
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 528134	J Med Chem. 2006 Apr 20;49(8):2526-33.4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.
Ref 528134	J Med Chem. 2006 Apr 20;49(8):2526-33.4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.

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