Drug Information

Drug General Information
Drug ID
D09CMJ
Former ID
DIB019873
Drug Name
FR122047
Synonyms
FR 122047; FR 122047 hydrochloride; FR-122047
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468249]
Structure
Download
2D MOL
Formula
C23H26ClN3O3S
InChI
InChI=1S/C23H25N3O3S.ClH/c1-25-12-14-26(15-13-25)23(27)22-24-20(16-4-8-18(28-2)9-5-16)21(30-22)17-6-10-19(29-3)11-7-17;/h4-11H,12-15H2,1-3H3;1H
InChIKey
YWMAVHIKOAOSFM-UHFFFAOYSA-N
PubChem Compound ID
196840
PubChem Substance ID
10262196, 14882470, 24724483, 26758501, 33516863, 51045572, 53800814, 57398686, 91746504, 99222753, 113463881, 125712065, 135173453, 135698270, 162247922, 163688335, 172658953, 178101879, 196379711, 202556891, 208265024, 215780143, 234940630, 241182486, 252325514
Target and Pathway
Target(s) Prostaglandin G/H synthase 1 Target Info Inhibitor [525724]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
Serotonergic synapse
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 468249(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5191).
Ref 525724The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models. Eur J Pharmacol. 2000 Mar 10;391(1-2):49-54.

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