Drug Information

Drug General Information
Drug ID
D09DHT
Former ID
DIB020710
Drug Name
phorbol 12-myristate 13-acetate
Synonyms
TPA; 12-O-tetradecanoylphorbol-13-acetate; tetradecanoyl-beta-phorbol acetate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539485]
Structure
Download
2D MOL
Formula
C36H56O8
InChI
InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
InChIKey
PHEDXBVPIONUQT-RGYGYFBISA-N
PubChem Compound ID
27924
PubChem Substance ID
7569, 139224, 492937, 596579, 3154907, 3288052, 7980341, 11120181, 11120669, 11121157, 11121697, 11122177, 11147264, 11342072, 11362255, 11362778, 11365340, 11367902, 11370807, 11370808, 11373503, 11374437, 11376064, 11404383, 11485638, 11487657, 11489727, 11492704, 14789656, 14838769, 17487166, 22391478, 24278653, 24887446, 24898219, 26613354, 26681074, 26681470, 26755285, 34670407, 46487935, 47290908, 47736218, 47885175, 48034851, 50110884, 53790708, 57244624, 57310548, 57652787
Target and Pathway
Target(s) KNa1.2 Target Info Inhibitor (gating inhibitor) [528200]
Transient receptor potential cation channel subfamily V member 4 Target Info Activator [526264]
KNa1.1 Target Info Activator [528200]
ATP-sensitive K+ channel Target Info Inhibitor (gating inhibitor) [526933]
KEGG Pathway Inflammatory mediator regulation of TRP channelshsa04713:Circadian entrainment
Retrograde endocannabinoid signaling
Serotonergic synapse
Dopaminergic synapse
Estrogen signaling pathway
Oxytocin signaling pathway
Morphine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome TRP channelsR-HSA-1296041:Activation of G protein gated Potassium channels
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways Calcium Regulation in the Cardiac Cell
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Notch Signaling Pathway
Potassium Channels
References
Ref 539485(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2341).
Ref 526264Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem. 2002 Apr 19;277(16):13569-77. Epub 2002 Feb 4.
Ref 526933Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1087-92. Epub 2004 Jan 19.
Ref 528200Opposite regulation of Slick and Slack K+ channels by neuromodulators. J Neurosci. 2006 May 10;26(19):5059-68.

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