Drug Information

Drug General Information
Drug ID
D09DIB
Former ID
DIB004058
Drug Name
RG-4929
Synonyms
R-4929; RO-5093151; 11-beta HSD inhibitor (type 2 diabetes), Roche; 11-beta hydroxysteroid dehydrogenase inhibitor (type 2 diabetes), Roche
Drug Type
Small molecular drug
Indication Metabolic disorders [ICD9: 270-279; ICD10:E70-E89] Phase 2 [523728]
Company
F Hoffmann-La Roche Ltd
Structure
Download
2D MOL

3D MOL
Formula
C23H27ClN2O2
Canonical SMILES
C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4.Cl
InChI
1S/C23H26N2O2.ClH/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18;/h1-10,20H,11-17H2,(H,24,26,27);1H
InChIKey
XSOOSXRNMDUWEM-UHFFFAOYSA-N
PubChem Compound ID
21846
PubChem Substance ID
8166086, 17397242, 29289212, 49637265, 49973060, 50612430, 56320322, 57330999, 85085237, 103669462, 104354415, 126410960, 134986993, 162090326, 163151152, 180126933, 226935234, 241108126
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 1 Target Info Inhibitor [551800]
KEGG Pathway Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis
NetPath Pathway IL1 Signaling Pathway
FSH Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 523728ClinicalTrials.gov (NCT01493271) A Study of RO5093151 in Patients With Ocular Hypertension Or Open Angle Glaucoma. U.S. National Institutes of Health.
Ref 551800New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131).

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