Drug Information

Drug General Information
Drug ID
D09FMK
Former ID
DNC004939
Drug Name
AM-630
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542520]
Structure
Download
2D MOL

3D MOL
Formula
C23H25IN2O3
InChI
InChI=1S/C23H25IN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3
InChIKey
JHOTYHDSLIUKCJ-UHFFFAOYSA-N
PubChem Compound ID
4302963
PubChem Substance ID
6319093, 7978679, 9633965, 11113929, 14835756, 35590692, 53787323, 57356907, 74936685, 85209557, 85787595, 91746245, 103445420, 104046922, 104253200, 112831395, 134342144, 135315120, 135649929, 135698378, 136368110, 137125126, 140908945, 144115586, 152258712, 152344478, 160647548, 160813319, 162022994, 162108975, 162111840, 162191100, 162220118, 162476483, 163374446, 163837880, 174007487, 185998781, 204432375, 223393074, 223592620, 223704294, 228646821, 241182146, 242059741, 248761352, 249823045, 249967165, 252059225, 252160266
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Inhibitor [529106]
Cannabinoid receptor 1 Target Info Inhibitor [529106]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 542520(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 750).
Ref 529106Bioorg Med Chem Lett. 2007 Dec 1;17(23):6505-10. Epub 2007 Oct 1.New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.

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