Drug General Information
Drug ID	D09GGO
Former ID	DIB005186
Drug Name	A-252444.0
Synonyms	A-155918; A-205804; A-241548
Indication	Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25]		Terminated	[547055]
Company	Abbott Laboratories
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(cc2c(s1)cncc2Sc1ccc(cc1)C)C(=O)N
Target and Pathway
Target(s)	ICAM-1	Target Info	Antagonist	[547056]
KEGG Pathway	NF-kappa B signaling pathway
	Cell adhesion molecules (CAMs)
	Natural killer cell mediated cytotoxicity
	TNF signaling pathway
	Leukocyte transendothelial migration
	African trypanosomiasis
	Malaria
	Staphylococcus aureus infection
	Influenza A
	HTLV-I infection
	Epstein-Barr virus infection
	Rheumatoid arthritis
	Viral myocarditis
NetPath Pathway	IL5 Signaling Pathway
	IL1 Signaling Pathway
	TSH Signaling Pathway
	IL6 Signaling Pathway
	IL2 Signaling Pathway
	ID Signaling Pathway
	TWEAK Signaling Pathway
	RANKL Signaling Pathway
	TNFalpha Signaling Pathway
Pathway Interaction Database	Thromboxane A2 receptor signaling
	Glucocorticoid receptor regulatory network
	amb2 Integrin signaling
	Beta2 integrin cell surface interactions
Reactome	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Integrin cell surface interactions
	Interferon gamma signaling
WikiPathways	Type II interferon signaling (IFNG)
	IL1 and megakaryotyces in obesity
	Human Complement System
	Spinal Cord Injury
	Interleukin-11 Signaling Pathway
	RANKL/RANK Signaling Pathway
	Integrin cell surface interactions
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
References
Ref 547055	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012566)
Ref 547056	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012566)

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