Drug General Information
Drug ID
D09HAD
Former ID
DNC005176
Drug Name
Drug 311383
Synonyms
311383
Indication Discovery agent Investigative [527143]
Structure
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2D MOL

3D MOL

Target and Pathway
Target(s) Presenilin 1 Target Info Inhibitor [527143]
Presenilin 2 Target Info Inhibitor [527143]
Gamma-secretase Target Info Inhibitor [527143]
KEGG Pathway Wnt signaling pathway
Notch signaling pathway
Neurotrophin signaling pathway
Alzheimer's diseasehsa04330:Notch signaling pathway
Alzheimer's disease
NetPath Pathway Notch Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Alzheimer disease-presenilin pathway
Notch signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Notch signaling pathway
Pathway Interaction Database Notch signaling pathway
Presenilin action in Notch and Wnt signaling
p75(NTR)-mediated signaling
Syndecan-3-mediated signaling eventslkb1_pathway:LKB1 signaling eventsnotch_pathway:Notch signaling pathway
Syndecan-3-mediated signaling events
Reactome Degradation of the extracellular matrixR-HSA-1251985:Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cellsR-HSA-1251985:Nuclear signaling by ERBB4
EPH-ephrin mediated repulsion of cells
WikiPathways Notch Signaling Pathway
Notch Signaling Pathway
Alzheimers DiseaseWP61:Notch Signaling Pathway
Signaling by ERBB4
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH1
Signaling by NOTCH2
Alzheimers Disease
Signalling by NGFWP61:Notch Signaling Pathway
Signalling by NGF
References
Ref 527143J Med Chem. 2004 Jul 29;47(16):3931-3.Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.
Ref 527143J Med Chem. 2004 Jul 29;47(16):3931-3.Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.

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