TTD | Drug: D09HTB

Drug General Information
Drug ID	D09HTB
Former ID	DCL000635
Drug Name	SAR153191
Indication	Ankylosing spondylitis [ICD9: 720; ICD10:M08.1, M45]		Phase 3	[542912], [548704]
Company	Sanofi-Aventis
Target and Pathway
Target(s)	Interleukin-6 receptor	Target Info	Antagonist	[549823]
KEGG Pathway	Cytokine-cytokine receptor interaction
	HIF-1 signaling pathway
	PI3K-Akt signaling pathway
	Jak-STAT signaling pathway
	Hematopoietic cell lineage
	Non-alcoholic fatty liver disease (NAFLD)
Reactome	MAPK3 (ERK1) activation
Reactome	MAPK1 (ERK2) activation
WikiPathways	SIDS Susceptibility Pathways
	Senescence and Autophagy in Cancer
	IL-6 signaling pathway
	Differentiation Pathway
	Interleukin-6 signaling
References
Ref 542912	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7999).
Ref 548704	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027858)
Ref 549823	Pharma & Vaccines. Product Development Pipeline. April 29 2009.

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Drug Information