Drug Information

Drug General Information
Drug ID
D09IHE
Former ID
DIB020402
Drug Name
MRK016
Synonyms
MRK-016; MRK 016
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467592]
Structure
Download
2D MOL
Formula
C17H20N8O2
InChI
InChI=1S/C17H20N8O2/c1-10-6-11(23-27-10)15-21-19-7-12-14(17(2,3)4)16(22-25(12)15)26-8-13-18-9-20-24(13)5/h6-7,9H,8H2,1-5H3
InChIKey
QYSYOGCIDRANAR-UHFFFAOYSA-N
PubChem Compound ID
6918583
PubChem Substance ID
12015556, 14926361, 17194976, 43529953, 74954567, 103458752, 104043363, 114788205, 138742160, 163122393, 178101074, 204366638, 228570330, 241376647, 249617990, 252157555
Target and Pathway
Target(s) Gamma-aminobutyric-acid receptor alpha-2 subunit Target Info Modulator
Gamma-aminobutyric-acid receptor alpha-3 subunit Target Info Modulator
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 467592(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4257).

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