Drug Information

Drug General Information
Drug ID
D09JGH
Former ID
DIB006598
Drug Name
EC-145
Synonyms
EC-0255; EC-0260
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 2 [522073]
Company
Endocyte; Merck
Structure
Download
2D MOL

3D MOL
Formula
C86H109N21O26S2
Canonical SMILES
N([C@H](C(=O)N[C@@H](CSSCCOC(=O)NNC(=O)[C@@]1([C@H]2[C@<br />@]3([C@@H]4[C@]([C@H]1O)(C=CCN4CC3)CC)c1c(N2C)cc(c([C@@<br />]2(c3c(c4c([nH]3)cccc4)CCN3C[C@](C[C@@H](C2)C3)(O)CC)C(<br />=O)OC)c1)OC)O)C(=O)O)CC(=O)O)C(=O)[C@@H](NC(=O)[C@H](CC<br />CNC(=N)N)NC(=O)[C@@H](NC(=O)CC[C@@H](C(=O)O)NC(=O)c1ccc<br />(cc1)NCc1cnc2c(n1)c(=O)[nH]c(n2)N)CC(=O)O)CC(=O)O
CAS Number
CAS 742092-03-1
PubChem Compound ID
25014653
Target and Pathway
Target(s) Folate receptor alpha Target Info Modulator [544306]
KEGG Pathway Endocytosis
Reactome COPII (Coat Protein 2) Mediated Vesicle Transport
Cargo concentration in the ER
WikiPathways Folate Metabolism
References
Ref 522073ClinicalTrials.gov (NCT00507741) Study of Vintafolide (MK-8109, EC145) in Participants With Advanced Ovarian and Endometrial Cancers (MK-8109-007, EC-FV-02). U.S. National Institutes of Health.
Ref 544306Significance of Folate Receptor alpha and Thymidylate Synthase Protein Expression in Patients with Non-Small Cell Lung Cancer treated with Pemetrexed. J Thorac Oncol. 2013 January; 8(1): 19-30.

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