Drug Information

Drug General Information
Drug ID
D09KYZ
Former ID
DIB010725
Drug Name
V-24343
Synonyms
CB1 antagonists, Vernalis; Cannabinoid CB1 receptor antagonists, Vernalis
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 1 [522402]
Company
Vernalis
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Antagonist [529987]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 522402ClinicalTrials.gov (NCT00734201) Safety and Efficacy of Low Doses of V24343 in Obese Subjects. U.S. National Institutes of Health.
Ref 529987Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis. Expert Opin Emerg Drugs. 2009 Mar;14(1):43-65.

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