Drug Information

Drug General Information
Drug ID
D09LTD
Former ID
DNC010388
Drug Name
S-Adenosylhomocysteine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540729]
Structure
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2D MOL

3D MOL
Formula
C14H20N6O5S
InChI
InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChIKey
ZJUKTBDSGOFHSH-WFMPWKQPSA-N
PubChem Compound ID
439155
PubChem Substance ID
3323, 583706, 583777, 584107, 584139, 584141, 584232, 585665, 585667, 819481, 821985, 822326, 823446, 823671, 823674, 823752, 823759, 823760, 825350, 825508, 826328, 826704, 826886, 826998, 827321, 827323, 827986, 828015, 828895, 828902, 828903, 829090, 829123, 829143, 829144, 829374, 829461, 829592, 829987, 830206, 830218, 831397, 831420, 831802, 831805, 831823, 832715, 832826, 833169, 833170
Target and Pathway
Target(s) DNA (cytosine-5)-methyltransferase Target Info Inhibitor [530577]
DNA (cytosine-5)-methyltransferase 3B Target Info Inhibitor [530577]
KEGG Pathway Cysteine and methionine metabolism
Metabolic pathways
MicroRNAs in cancer
Reactome PRC2 methylates histones and DNA
NoRC negatively regulates rRNA expression
DNA methylation
WikiPathways Mesodermal Commitment Pathway
Endoderm Differentiation
Trans-sulfuration and one carbon metabolism
One Carbon Metabolism
miR-targeted genes in lymphocytes - TarBase
References
Ref 540729(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5265).
Ref 530577Bioorg Med Chem. 2010 Jan 15;18(2):822-9. Epub 2009 Nov 27.Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation.

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