TTD | Drug: D09MKQ

Drug General Information
Drug ID	D09MKQ
Former ID	DCL000424
Drug Name	AMG 317
Indication	Asthma [ICD10:J45]		Discontinued in Phase 1	[547559]
Company	Amgen
Target and Pathway
Target(s)	Interleukin-4 receptor alpha chain	Target Info	Antagonist	[550250], [551086]
KEGG Pathway	Cytokine-cytokine receptor interaction
	PI3K-Akt signaling pathway
	Jak-STAT signaling pathway
	Hematopoietic cell lineage
	Inflammatory bowel disease (IBD)
NetPath Pathway	IL2 Signaling Pathway
	IL4 Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	Interleukin signaling pathway
Pathway Interaction Database	p73 transcription factor network
Pathway Interaction Database	IL4-mediated signaling events
WikiPathways	Inflammatory Response Pathway
WikiPathways	IL-4 Signaling Pathway
References
Ref 547559	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017312)
Ref 550250	Clinical pipeline report, company report or official report of Amgen (2009).
Ref 551086	Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease. Inflamm Bowel Dis. 2010 Jul;16(7):1209-18.

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Drug Information