Drug General Information
Drug ID	D09MOD
Former ID	DIB005310
Drug Name	NNC-252504
Synonyms	Glucagon antagonists, Agouron/Novo Nordisk; NNC-25-0926; NNC-25-2504; NNC-25-2648
Indication	Type 2 diabetes [ICD9: 250; ICD10:E11]		Terminated	[547264]
Company	Agouron Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	n1(Cc2c(c(cc(c2C)C)C)C)c2c(cc1)c(/C=N/NC(=O)c1cc(C#N)c(<br />cc1)O)ccc2
Target and Pathway
Target(s)	Glucagon receptor	Target Info	Antagonist	[528683]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Glucagon signaling pathway
Reactome	Glucagon signaling in metabolic regulation
	G alpha (q) signalling events
	G alpha (s) signalling events
	Glucagon-type ligand receptors
WikiPathways	GPCRs, Class B Secretin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 547264	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014586)
Ref 528683	A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog. J Pharmacol Exp Ther. 2007 May;321(2):743-52. Epub 2007 Feb 16.

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