TTD | Drug: D09MON

Drug General Information
Drug ID	D09MON
Former ID	DIB011328
Drug Name	A-75998
Indication	Hormone deficiency [ICD10:E00-E90]		Discontinued in Phase 1	[545556]
Company	Abbott Laboratories
Structure		Download 2D MOL 3D MOL
Formula	C80H104ClN15O14
Canonical SMILES	N1(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](N(<br />C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)C<br />)Cc2cc3c(cc2)cccc3)Cc2ccc(Cl)cc2)Cc2cnccc2)CO)C)Cc2ccc(<br />cc2)O)CCCCNC(=O)c2cnccc2)CC(C)C)CCCCNC(C)C)[C@H](C(=O)N<br />[C@@H](C(=O)N)C)CCC1
CAS Number	CAS 135215-95-1
PubChem Compound ID	44383749
Target and Pathway
Target(s)	Gonadotropin-releasing hormone receptor	Target Info	Antagonist	[533603]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	GnRH signaling pathway
NetPath Pathway	IL1 Signaling Pathway
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Hormone ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 545556	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003694)
Ref 533603	Physicochemical properties of A-75998, an antagonist of luteinizing hormone releasing hormone. J Pharm Sci. 1995 Aug;84(8):953-8.

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Drug Information