Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09NMD
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| Former ID |
DAP001445
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| Drug Name |
Lasofoxifene
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| Synonyms |
Oporia; Lasofoxifene [INN]; CP 336156; CP-336,156; Cis-1R-(4'-pyrrolidinoethoxyphenyl)-2S-phenyl-6-hydroxy-1,2,3,4-tetrahydronaphthalene, tartrate salt; (5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
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| Drug Type |
Small molecular drug
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| Company |
Pfizer
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| Structure |
|
Download2D MOL |
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| Formula |
C28H31NO2
|
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| InChI |
InChI=1S/C28H31NO2/c30-24-11-15-27-23(20-24)10-14-26(21-6-2-1-3-7-21)28(27)22-8-12-25(13-9-22)31-19-18-29-16-4-5-17-29/h1-3,6-9,11-13,15,20,26,28,30H,4-5,10,14,16-19H2/t26-,28+/m1/s1
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| InChIKey |
GXESHMAMLJKROZ-IAPPQJPRSA-N
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| CAS Number |
CAS 180916-16-9
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9372902, 14831231, 14904412, 24770716, 30420129, 49688680, 50075362, 50359465, 53787068, 57399782, 103314903, 113461635, 126667068, 128019372, 134338645, 134339082, 135136354, 135341628, 136946558, 137115371, 142314011, 144116131, 163125974, 164228137, 164834342, 179150118, 187051843, 198945374, 204370304, 223662242, 223741437, 226414580
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| Target and Pathway | |||||
| Target(s) | Estrogen receptor | Target Info | Modulator | [549974] | |
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| Signaling events mediated by HDAC Class II | |||||
| Plasma membrane estrogen receptor signaling | |||||
| LKB1 signaling events | |||||
| Regulation of Telomerase | |||||
| ATF-2 transcription factor network | |||||
| AP-1 transcription factor network | |||||
| FOXM1 transcription factor network | |||||
| Validated nuclear estrogen receptor alpha network | |||||
| Signaling mediated by p38-alpha and p38-beta | |||||
| FOXA1 transcription factor network | |||||
| References | |||||
| Ref 542544 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7542). | ||||
| Ref 549974 | Pfizer. Product Development Pipeline. March 31 2009. | ||||
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