Drug Information

Drug General Information
Drug ID
D09NTC
Former ID
DNCL003453
Drug Name
CC-486
Synonyms
Nucleoside analogue
Drug Type
Small molecular drug
Indication Myelodysplastic syndrome [ICD9: 238.7; ICD10:D46] Phase 3 [549703]
Company
Celgene
Structure
Download
2D MOL

3D MOL
Formula
C19H20N4O
Canonical SMILES
CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3N2CCNC4=O
InChI
1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H,10-12H2,1-2H3,(H,20,24)
InChIKey
SEKJSSBJKFLZIT-UHFFFAOYSA-N
PubChem Compound ID
9840076
PubChem Substance ID
14801398, 24138480, 44938160, 49645682, 75980483, 99431558, 99460875, 103261452, 104015396, 104253502, 124757624, 124792817, 125164428, 136340148, 136920261, 137275824, 140105717, 152258354, 160647192, 162011827, 162037796, 162202721, 163908012, 164194027, 165247593, 172649965, 174528919, 178118772, 179551797, 185990463, 198960971, 223396135, 223704418, 231943732, 247394852, 249565774, 251962950, 252109983, 252214684, 252436436
Target and Pathway
Target(s) DNMT1 Target Info Inhibitor [533326]
KEGG Pathway Cysteine and methionine metabolism
Metabolic pathways
MicroRNAs in cancer
Pathway Interaction Database Regulation of retinoblastoma protein
PathWhiz Pathway Methionine Metabolism
Reactome PRC2 methylates histones and DNA
NoRC negatively regulates rRNA expression
DNA methylation
WikiPathways Trans-sulfuration and one carbon metabolism
Retinoblastoma (RB) in Cancer
One Carbon Metabolism
Trans-sulfuration pathway
References
Ref 549703J Clin Oncol 33, 2015 (suppl, abstr TPS7097).
Ref 533326Efficacy and safety of extended dosing schedules of CC-486 (oral azacitidine) in patients with lower-risk myelodysplastic syndromes. Leukemia. 2015 Oct 7.

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