Drug Information

Drug General Information
Drug ID
D09OBX
Former ID
DIB019940
Drug Name
GSK Compound 34
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540442]
Formula
C22H20FN3O4
InChI
InChI=1S/C22H20FN3O4/c1-26-10-17(16-8-13(23)5-6-18(16)26)20-19(21(29)25-22(20)30)12-3-2-4-14(7-12)24-9-15(28)11-27/h2-8,10,15,24,27-28H,9,11H2,1H3,(H,25,29,30)
InChIKey
RPGZQOOZHIEPJW-UHFFFAOYSA-N
PubChem Compound ID
11560568
PubChem Substance ID
16662823, 23680424, 42702459, 51338428, 103738510, 104147351, 137184271, 142243061, 170501518, 178100489, 180060518, 185988950, 230261305, 238944828, 243170336, 252154028, 252810409
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Antagonist [543887]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540442(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3502).
Ref 543887(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59).

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