Drug General Information
Drug ID
D09OHS
Former ID
DIB018613
Drug Name
4alpha-PDD
Synonyms
4alpha-phorbol 12,13-didecanoate; 4alpha-phorbol-didecanoate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539624]
Structure
Download
2D MOL
Formula
C40H64O8
InChI
InChI=1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1
InChIKey
DGOSGFYDFDYMCW-OEFRVDPMSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily V member 4 Target Info Activator [526264]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
Ref 539624(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2500).
Ref 526264Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem. 2002 Apr 19;277(16):13569-77. Epub 2002 Feb 4.

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