Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09PRG
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| Former ID |
DIB018281
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| Drug Name |
[3H]eglumegad
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| Synonyms |
[3H]LY354740
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C8H11NO4
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| InChI |
InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
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| InChIKey |
VTAARTQTOOYTES-RGDLXGNYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7979829, 9371121, 14748421, 15171407, 30417292, 49893662, 57399664, 76123878, 96025591, 99374044, 103066678, 103078431, 103167812, 103952580, 113453194, 117518357, 126681491, 129522756, 134222157, 134338837, 134342627, 135188014, 135650554, 135651173, 137008428, 141864460, 143494992, 152039494, 152165111, 152238648, 162221554, 163304092, 163346685, 170485584, 198977294, 202548619, 204373912, 223661924, 223886305, 225144924, 226393133, 226797883, 249727659, 252213797
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| Target and Pathway | |||||
| Target(s) | Metabotropic glutamate receptor 2 | Target Info | Agonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Glutamatergic synapse | |||||
| Cocaine addiction | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Ionotropic glutamate receptor pathway | |||||
| Metabotropic glutamate receptor group II pathway | |||||
| Reactome | G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | ||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1396). | ||||
| REF 2 | Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors. Neuropharmacology. 2000 Jul 24;39(10):1700-6. | ||||
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