Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09PZD
|
||||
| Former ID |
DIB021160
|
||||
| Drug Name |
viral macrophage inflammatory protein-II
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [542659] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C55H93N19O14S2
|
||||
| InChI |
InChI=1S/C55H93N19O14S2/c1-28(2)23-37-50(84)74-43(30(5)75)52(86)69-35(15-9-10-20-56)47(81)67-33(16-11-21-63-54(59)60)45(79)65-25-41(77)66-34(17-12-22-64-55(61)62)46(80)68-36(18-19-40(58)76)48(82)73-42(29(3)4)51(85)72-39(53(87)88)27-90-89-26-32(57)44(78)70-38(49(83)71-37)24-31-13-7-6-8-14-31/h6-8,13-14,28-30,32-39,42-43,75H,9-12,15-27,56-57H2,1-5H3,(H2,58,76)(H,65,79)(H,66,77)(H,67,81)(H,68,80)(H,69,86)(H,70,78)(H,71,83)(H,72,85)(H,73,82)(H,74,84)(H,87,88)(H4,59,60,63)(H4,61,62,64)/t30-,32+,33+,34+,35+,36+,37+,38+,39+,42+,43+/m1/s1
|
||||
| InChIKey |
JOEHPBQVSCDCHE-BKGQOYFSSA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | CC chemokine receptor | Target Info | Antagonist | [534456] | |
| C-X-C chemokine receptor 4 | Target Info | Antagonist | [534456] | ||
| C-C chemokine receptor type 8 | Target Info | Antagonist | [525544] | ||
| C-C chemokine receptor type 2 | Target Info | Antagonist | [534456] | ||
| mRNA of CCR5 | Target Info | Antagonist | [534456] | ||
| KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
| Chemokine signaling pathwayhsa04060:Cytokine-cytokine receptor interaction | |||||
| Chemokine signaling pathway | |||||
| Endocytosis | |||||
| Axon guidance | |||||
| Leukocyte transendothelial migration | |||||
| Intestinal immune network for IgA production | |||||
| Pathways in cancerhsa04060:Cytokine-cytokine receptor interaction | |||||
| Viral carcinogenesishsa04060:Cytokine-cytokine receptor interaction | |||||
| Toxoplasmosis | |||||
| Viral carcinogenesis | |||||
| PANTHER Pathway | Axon guidance mediated by Slit/Robo | ||||
| Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway | |||||
| Reactome | Beta defensins | ||||
| Binding and entry of HIV virion | |||||
| Chemokine receptors bind chemokines | |||||
| G alpha (i) signalling eventsR-HSA-173107:Binding and entry of HIV virion | |||||
| G alpha (i) signalling eventsR-HSA-380108:Chemokine receptors bind chemokines | |||||
| G alpha (i) signalling eventsR-HSA-1461957:Beta defensins | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like | |||||
| Hematopoietic Stem Cell Differentiation | |||||
| HIV Life Cycle | |||||
| Cardiac Progenitor Differentiation | |||||
| Defensins | |||||
| Spinal Cord Injury | |||||
| GPCR downstream signalingWP69:TCR Signaling Pathway | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| Ref 525544 | HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines. J Biol Chem. 1999 Jul 30;274(31):21569-74. | ||||
| Ref 534456 | A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science. 1997 Sep 12;277(5332):1656-9. | ||||
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