Drug Information

Drug General Information
Drug ID
D09QDP
Former ID
DAP001361
Drug Name
Clorgyline
Synonyms
Chlorgyline; Clorgilin; Clorgilina; Clorgiline; Clorgilinum; Clorgiline [INN]; M and B 9302; Clorgilina [INN-Spanish]; Clorgiline (INN); Clorgilinum [INN-Latin]; M & B 9302; N-methyl-n-propargyl-3-(2,4-dichlorophenoxy)propylamine; N-(3-(2,4-Dichlorophenoxy)propyl)-N-methyl-2-propynylamine; N-[3-(2,4-DICHLOROPHENOXY)PROPYL]-N-METHYL-N-PROP-2-YNYLAMINE; 2-Propyn-1-amine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-(9CI); 3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine
Drug Type
Small molecular drug
Indication Parkinson's disease; Major depressive disorder [ICD9: 332, 296.2, 296.3, 710.0; ICD10:G20, F32, F33, M32] Approved [537290], [541746], [551871]
Therapeutic Class
Antiparkinson Agents
Structure
Download
2D MOL

3D MOL
Formula
C13H15Cl2NO
InChI
InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3
InChIKey
BTFHLQRNAMSNLC-UHFFFAOYSA-N
CAS Number
CAS 17780-72-2
PubChem Compound ID
4380
PubChem Substance ID
13850, 3249453, 5551145, 7888938, 8152714, 11111452, 11111453, 11466372, 11467492, 11486064, 15197430, 17397401, 29223477, 46507410, 46515873, 47216895, 47736618, 47959893, 48259379, 48334629, 49698444, 50026762, 50111129, 53787182, 57322251, 57389000, 74906189, 85209991, 85787507, 89449655, 90341614, 103167716, 104306235, 121598837, 124749963, 124880698, 126407870, 127564762, 134338573, 134993341, 137237445, 137725548, 160967085, 163425653, 163667991, 178103249, 179148711, 196408559, 198975950, 226443490
Target and Pathway
Target(s) Amine oxidase [flavin-containing] A Target Info Inhibitor [537290]
BioCyc Pathway Superpathway of tryptophan utilization
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradation
Serotonin degradation
Superpathway of melatonin degradation
Melatonin degradation II
KEGG Pathway Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholism
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathway
PathWhiz Pathway Histidine Metabolism
Tyrosine Metabolism
Glycine and Serine Metabolism
Reactome Norepinephrine Neurotransmitter Release Cycle
WikiPathways SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Oxidative Stress
Dopamine metabolism
Phase 1 - Functionalization of compounds
Neurotransmitter Release Cycle
Neurotransmitter Clearance In The Synaptic Cleft
Serotonin Transporter Activity
References
Ref 537290Further investigation into the mechanism of tachykinin NK(2) receptor-triggered serotonin release from guinea-pig proximal colon. J Pharmacol Sci. 2009 May;110(1):122-6. Epub 2009 May 8.
Ref 541746(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6636).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537290Further investigation into the mechanism of tachykinin NK(2) receptor-triggered serotonin release from guinea-pig proximal colon. J Pharmacol Sci. 2009 May;110(1):122-6. Epub 2009 May 8.

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