TTD | Drug: D09QLR

Drug General Information
Drug ID	D09QLR
Former ID	DIB012446
Drug Name	Dibenzothiazepines
Synonyms	Cannabinoid CB1 inverse agonists (CNS disorder); Cannabinoid CB1 inverse agonists (CNS disorder), ACADIA; CB1 inverse agonists (obesity, substance abuse), ACADIA
Indication	Drug abuse [ICD9: 303-304; ICD10:F10-F19]		Investigative	[552047]
Company	ACADIA Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1c(cc(c(c1)F)Cl)C1=Nc2cc(ccc2Sc2c1cccc2)C(=O)NCCCC
Target and Pathway
Target(s)	Cannabinoid receptor 1	Target Info	Agonist	[543877]
KEGG Pathway	Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
PANTHER Pathway	Endogenous cannabinoid signaling
Pathway Interaction Database	N-cadherin signaling events
Reactome	Class A/1 (Rhodopsin-like receptors)
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	BDNF signaling pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 552047	Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists. J Med Chem. 2009 Apr 9;52(7):1975-82
Ref 543877	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).

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Drug Information