TTD | Drug: D09SHX

Drug General Information
Drug ID	D09SHX
Former ID	DIB007699
Drug Name	GM-CSF cancer vaccine
Drug Type	Vaccine
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Phase 2	[551058]
Company	Thomas Jefferson University
Target and Pathway
Target(s)	Granulocyte-macrophage colony-stimulating factor receptor alpha chain	Target Info		[543463]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Hematopoietic cell lineage
	Pathways in cancer
NetPath Pathway	IL3 Signaling Pathway
NetPath Pathway	RANKL Signaling Pathway
Pathway Interaction Database	GMCSF-mediated signaling events
Pathway Interaction Database	Alpha9 beta1 integrin signaling events
Reactome	GPVI-mediated activation cascade
	G beta:gamma signalling through PI3Kgamma
	Interleukin-3, 5 and GM-CSF signaling
	RAF/MAP kinase cascade
	Surfactant metabolism
	Interleukin receptor SHC signaling
WikiPathways	Interleukin-2 signaling
WikiPathways	Interleukin-3, 5 and GM-CSF signaling
References
Ref 551058	A safety and efficacy trial of lethally irradiated allogeneic pancreatic tumor cells transfected with the GM-CSF gene in combination with adjuvant chemoradiotherapy for the treatment of adenocarcinoma of the pancreas. Journal of Clinical Oncology, Vol 25, No 18S (June 20 Supplement), 2007: 3010.
Ref 543463	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1707).

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Drug Information