Drug Information

Drug General Information
Drug ID
D09SSC
Former ID
DIB009016
Drug Name
Nipradilol
Drug Type
Small molecular drug
Indication Angina pectoris [ICD9: 413; ICD10:I20] Approved [551871]
Structure
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2D MOL

3D MOL
Formula
C15H22N2O6
Canonical SMILES
[N+](=O)(OC1Cc2c(OC1)c(OCC(CNC(C)C)O)ccc2)[O-]
PubChem Compound ID
72006
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Modulator [533522], [551871]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 533522Actions of nipradilol (K-351), a new alpha- and beta-adrenoceptor blocker, on the rabbit portal vein. Jpn J Pharmacol. 1984 Aug;35(4):359-69.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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